Topical use of B. lactis HN019 promotes a protective effect against alveolar bone and connective tissue attachment losses.
J Periodontol. 2016 Sep 23:1-20. Epub 2016 Sep 23. PMID: 27660886
Benefits of Bifidobacterium Animalis Subsp Lactis Probiotic in Experimental Periodontitis.
BACKGROUND: This study evaluated the effects of topical administration of probiotic bacteria (PROB) of the genus Bifidobacterium on experimental periodontitis (EP) in rats.METHODS: 32 rats were divided into groups C (control; without EP), EP (EP only), C-HN019 (control+PROB) and EP-HN019 (EP+PROB). On day 0 of the experiment, animals of groups EP and EP-HN019 received cotton ligatures around mandibular first molars (MFM). In groups C-HN019 and EP-HN019, 1mL of suspensions containing Bifidobacterium animalis subsp lactis (B. lactis) HN019 was topically administered in the subgingival region of MFM on days 0, 3 and 7. In groups C and EP, topical administrations were performed using a sham suspension (without PROB). All animals were euthanized at day 14. Gingival tissue, hemi-mandibles and oral biofilm were collected. Data were statistically analyzed (P